Fredrik Almqvist: Design, Synthesis & Evaluation of novel antibacterial agents and protein aggregation inhibitors

Design, Synthesis & Evaluation of Ring fused 2-Pyridones Directed at Different Medicinal Targets and Diverse Oriented Synthesis (DOS) Towards New Heterocyclic Scaffolds.

Fredrik AlmqvistA chemical platform with broad applications and flexibility has been rationally designed to interrupt complicated molecular machines important in microbial pathogenesis. The research programme contains a blend of computer-aided design, synthetic organic chemistry, molecular biology and genetics to investigate and disrupt complex biological systems important in disease processes.

Publications

Author

Title

Year sorteringsordning

Fulltext

Basu, Basudeb
Paul, Susmita
Kundu, Samir; et al.

Organic Polymeric Resins Embedded with Pd NPs: Newly Designed, Efficient and Chemoselective Catalyst for Reduction of Nitrobenzenes
Current Organocatalysis, 4(1): 48-61

2017

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Wixe, Torbjörn
Almqvist, Fredrik

An improved synthesis of 3-[1-(trifluoromethy1)-3H-1,2-diazirin-3-yl] aniline: a key intermediate in the synthesis of photoaffinity probes
Tetrahedron Letters, 58(34): 3350-3352

2017

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Jain, Neha
Ådén, Jörgen
Nagamatsu, Kanna; et al.

Inhibition of curli assembly and Escherichia coli biofilm formation by the human systemic amyloid precursor transthyretin
Proceedings of the National Academy of Sciences, 114(46): 12184-12189

2017

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Good, James A. D.
Kulén, Martina
Silver, Jim; et al.

Thiazolino 2-pyridone amide isosteres as inhibitors of Chlamydia trachomatis infectivity
Journal of Medicinal Chemistry, 60(22): 9393-9399

2017

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Pokrzywa, Malgorzata
Pawelek, Katarzyna
Kucia, Weronika Elzbieta; et al.

Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease
PLoS ONE, 12(9)

2017

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Good, James A. D.
Andersson, Christopher
Hansen, Sabine; et al.

Attenuating Listeria monocytogenes virulence by targeting the regulatory protein PrfA
Cell chemical biology, 23(3): 404-414

2016

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Good, James A. D.
Silver, Jim
Nunez-Otero, Carlos; et al.

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity
Journal of Medicinal Chemistry, 59(5): 2094-2108

2016

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Hall, Michael
Grundström, Christin
Begum, Afshan; et al.

Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria
Proceedings of the National Academy of Sciences of the United States of America, 113(51): 14733-14738

2016

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Barange, Deepak Kumar
Johnson, Magnus T.
Cairns, Andrew G.; et al.

Regio- and Stereoselective Alkylation of Pyridine-N-oxides: Synthesis of Substituted Piperidines and Pyridines
Organic Letters, 18(24): 6228-6231

2016

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Varga, M G
Shaffer, C L
Sierra, J C; et al.

Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system
Oncogene, 35(48): 6262-6269

2016

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