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Fredrik Almqvist: Design, Synthesis & Evaluation of novel antibacterial agents and protein aggregation inhibitors

Design, Synthesis & Evaluation of Ring fused 2-Pyridones Directed at Different Medicinal Targets and Diverse Oriented Synthesis (DOS) Towards New Heterocyclic Scaffolds.

Fredrik AlmqvistA chemical platform with broad applications and flexibility has been rationally designed to interrupt complicated molecular machines important in microbial pathogenesis. The research programme contains a blend of computer-aided design, synthetic organic chemistry, molecular biology and genetics to investigate and disrupt complex biological systems important in disease processes.

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Basu, Basudeb
Paul, Susmita
Kundu, Samir; et al.

Organic Polymeric Resins Embedded with Pd NPs: Newly Designed, Efficient and Chemoselective Catalyst for Reduction of Nitrobenzenes
Current Organocatalysis, 4(1): 48-61

2017

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Good, James A. D.
Andersson, Christopher
Hansen, Sabine; et al.

Attenuating Listeria monocytogenes virulence by targeting the regulatory protein PrfA
Cell chemical biology, 23(3): 404-414

2016

Hämta

Good, James A. D.
Silver, Jim
Nunez-Otero, Carlos; et al.

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity
Journal of Medicinal Chemistry, 59(5): 2094-2108

2016

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Hall, Michael
Grundström, Christin
Begum, Afshan; et al.

Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria
Proceedings of the National Academy of Sciences of the United States of America, 113(51): 14733-14738

2016

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Barange, Deepak Kumar
Johnson, Magnus T.
Cairns, Andrew G.; et al.

Regio- and Stereoselective Alkylation of Pyridine-N-oxides: Synthesis of Substituted Piperidines and Pyridines
Organic Letters, 18(24): 6228-6231

2016

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Varga, M G
Shaffer, C L
Sierra, J C; et al.

Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system
Oncogene, 35(48): 6262-6269

2016

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Shaffer, Carrie L.
Good, James A. D.
Kumar, Santosh; et al.

Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens
mBio, 7(2)

2016

Hämta

Chermenina, Maria
Chorell, Erik
Pokrzywa, Malgorzata; et al.

Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice
Parkinson's Disease, 1

2015

Hämta

Chorell, Erik
Andersson, Emma
Evans, Margery L.; et al.

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts
PLoS ONE, 10(10): 1-11

2015

Hämta

Singh, Pardeep
Chorell, Erik
Krishnan, K Syam; et al.

Synthesis of multiring fused 2‑pyridones via a nitrene insertion reaction: fluorescent modulators of α‑synuclein amyloid formation
Organic Letters, 17(24): 6194-6197

2015

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Sidansvarig: Fredrik Almqvist

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